General information
    ACovPid:ACoVP100313
    Trivial Name:FFS
    Amino Acids Sequence:FEEFSKKFEEFSKKFEEFSKKFEEFSKKFEEFSKK-βA-K(C16)
    Length:
    C-Terminal Modification:(C16): palmitoyl group;  
    N-Terminal Modification:None
    Chemical Modification:βA: β-alanine;  
    Peptide Source:
    Source Description:Initially, the author aimed to establish combinations of foregrounda-d residues in the heptad repeat moiety. As previous experiments have indicated that alanine residues are strongly biased toward helix formation in peptides,38 the design of the novel lip
    Against Virus:

    The Middle East respiratory syndrome coronavirus (MERS-CoV)

    Inhibition Value Type:EC50
    Inhibitory Effect:3.11 ± 0.9
    Inhibitory Unit:µM
    Target Domain Name:
    Assay:Cell–cell fusion assay
    Assay Description:The target cells were Huh-7 cells expressing the MERS-CoV receptor dipeptidyl peptidase 4. The effector cells were 293T/MERS/enhanced GFP protein (EGFP) cells. The 293T/MERS/EGPF cells contained the MERS-CoV S protein gene and the EGFP gene transfected with plasmid. The 293T/EGFP cells expressing only EGFP were employed as negative control cells. Huh-7 cells were plated in 96-well plates (5 × 10^4 cells/well) at 37 °C for 5 h. Then, serially diluted peptide samples were added, followed by the addition of 293T/MERS/EGPF cells or 293T/EGFP cells (1 × 10^4 cells/well). After coculturing at 37 °C for 4 h, the 293T/MERS/EGFP cells and 293T/EGFP cells, either fused or unfused, with Huh-7 cells were counted under an inverted fluorescence microscope (Nikon Eclipse Ti-S).
    Anti-CoV activity in vivo:
    Reference:30192544
    Comment:
    3D structure:

    Structure Experiment Verified:
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