General information
    ACovPid:ACoVP100208
    Trivial Name:P6 + P8
    Amino Acids Sequence:P6: YQDVNCTDVSTAIHADQLTP; P8: QYGSFCTQLNRALSGIAAEQ;
    Length:
    C-Terminal Modification:None
    N-Terminal Modification:None
    Chemical Modification:None
    Peptide Source:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Source Description:
    Against Virus:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Inhibition Value Type:IC90
    Inhibitory Effect:9.6 ± 1.9
    Inhibitory Unit:µg/mL
    Target Domain Name:S1 domain of SARS-CoV
    Assay:Cytopathic effect (CPE) inhibition assay (peptide combinations)
    Assay Description:To test whether combinations of peptides targeting different domains exhibited synergistic antiviral effects, FRhK-4 cells were pre-treated with mixtures of two active peptides 1 h before infection, using equal amounts of each peptide and total concentrations of 100, 50 and 25 µg/ml, respectively. Samples were collected at 36 h post-infection for viral titre determination (Figure 5A) and viral RNA quantification.
    Anti-CoV activity in vivo:
    Reference:15918330
    Comment:The highest synergistic antiviral effectwas observed in the combination of P6 and P8 at100 µg/ml, in which viral titre was reduced at least 10000-fold. The IC 90of P6+P8 was reduced by about12-fold, as compared with P6 alone (IC909.6 µg/ml vs IC90 113.0 µg/ml) and 2.5-fold as compared with P8alone (IC90 9.6 µg/ml vs IC 90 24.9 µg/ml)
    3D structure:

    Structure Experiment Verified:
    Similar Peptides:

    Target Domain information
    Target Domain Full Name:S1 domain of Severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein
    Target Type:glycoprotein
    UniprotID [Sequence]:

    P59594 [12–672]

    Target Synonyms:Alternative name(s) for spike glycoprotein: E2 Peplomer protein S glycoprotein
    Target Source:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Target Structure:1WNC, 1WYY, 1ZV7, 1ZV8, 1ZVB, 2AJF, 2BEQ, 2BEZ, 2DD8, 2FXP, 2GHV, 2GHW, 2RUM, 2RUN, 2RUO, 3BGF, 3D0G, 3D0H, 3D0I, 3SCI, 3SCJ, 3SCK, 3SCL, 5WRG, 5X4S, 5X58, 5X5B, 5XJK, 5XLR, 5ZVM, 6ACC, 6ACD, 6ACG, 6ACJ, 6ACK, 6CRV, 6CRW, 6CRX, 6CRZ, 6CS0, 6CS1, 6CS2, 6M3W, 6NB6, 6NB7, 6VW1, 6WAQ, 7JN5