General information
    ACovPid:ACoVP100195
    Trivial Name:P1
    Amino Acids Sequence:FKLPLGINITNFRAILTAFS
    Length:20
    C-Terminal Modification:None
    N-Terminal Modification:None
    Chemical Modification:None
    Peptide Source:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Source Description:
    Against Virus:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Inhibition Value Type:IC90
    Inhibitory Effect:>500
    Inhibitory Unit:µg/mL
    Target Domain Name:S1 domain of SARS-CoV
    Assay:Cytopathic effect (CPE) inhibition assay
    Assay Description:FRhK-4 cells seeded in 96-well plates were separately incubated with each peptide at a concentration of 25, 50 and 100 µg/ml starting 1 h before infection with SARS-CoV at 0.05 MOI. CPEs were determined 36 h post-infection to evaluate peptide-mediated protection from viral infection. None of the 10 peptide-treated cells exhibited cytotoxic effects at the concentrations tested. In untreated cells, the CPEs observed after 36 h were typified by cell rounding and detachment.
    Anti-CoV activity in vivo:
    Reference:15918330
    Comment:
    3D structure:

    StructureACoVP100195

    Structure Experiment Verified:NO
    Similar Peptides:ACoVP100507   

    Target Domain information
    Target Domain Full Name:S1 domain of Severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein
    Target Type:glycoprotein
    UniprotID [Sequence]:

    P59594 [12–672]

    Target Synonyms:Alternative name(s) for spike glycoprotein: E2 Peplomer protein S glycoprotein
    Target Source:

    Severe acute respiratory syndrome coronavirus (SARS-CoV) : 694009

    Target Structure:1WNC, 1WYY, 1ZV7, 1ZV8, 1ZVB, 2AJF, 2BEQ, 2BEZ, 2DD8, 2FXP, 2GHV, 2GHW, 2RUM, 2RUN, 2RUO, 3BGF, 3D0G, 3D0H, 3D0I, 3SCI, 3SCJ, 3SCK, 3SCL, 5WRG, 5X4S, 5X58, 5X5B, 5XJK, 5XLR, 5ZVM, 6ACC, 6ACD, 6ACG, 6ACJ, 6ACK, 6CRV, 6CRW, 6CRX, 6CRZ, 6CS0, 6CS1, 6CS2, 6M3W, 6NB6, 6NB7, 6VW1, 6WAQ, 7JN5